BDBM50527313 CHEMBL4446917::US10829446, Compound 137

SMILES CCOc1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F

InChI Key InChIKey=FADSDPNPNCFOBJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50527313   

TargetHistone acetyltransferase KAT6A [507-778](Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50527313(CHEMBL4446917 | US10829446, Compound 137)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of recombinant KAT6A (unknown origin) expressed in C57BL/6 mouse embryonic fibroblasts assessed as reduction in cell proliferation supplem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT6A [507-778](Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50527313(CHEMBL4446917 | US10829446, Compound 137)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT6A [507-778](Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50527313(CHEMBL4446917 | US10829446, Compound 137)
Affinity DataIC50: 62nMAssay Description:Active Moz protein was expressed as N-terminal fusion protein with a His6 tag in BL21 E. coli cells. Protein purification was performed via nickel-im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent