BDBM50527633 CHEMBL4464812

SMILES CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(NCc3ccc(cc3)C(=O)NO)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=XBZDKDNYELJFTM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50527633   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527633(CHEMBL4464812)
Affinity DataIC50: 50nMAssay Description:Inhibition of human PI3Kalpha assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527633(CHEMBL4464812)
Affinity DataIC50: 45nMAssay Description:Inhibition of human PI3Kgamma assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527633(CHEMBL4464812)
Affinity DataIC50: 32nMAssay Description:Inhibition of human PI3Kdelta assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527633(CHEMBL4464812)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1125 residues) expressed in baculovirus infected insect cells using fluorogenic pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527633(CHEMBL4464812)
Affinity DataIC50: 842nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed