BDBM50527647 CHEMBL4454039

SMILES Clc1ccc(Cn2nccc2-c2cc(Cl)c3nnn(-c4ccc5cn[nH]c5c4)c3c2)nc1

InChI Key InChIKey=ZDOABTDZRAJXOA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50527647   

Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527647(CHEMBL4454039)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human CD73 expressed in CHO cells in 2 % DMSO using AMP as substrate preincubated for 60 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527647(CHEMBL4454039)
Affinity DataIC50: 55nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527647(CHEMBL4454039)
Affinity DataIC50: 300nMAssay Description:Inhibition of human liver microsome CYP2C19 using S-mephenytoin as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527647(CHEMBL4454039)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527647(CHEMBL4454039)
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527647(CHEMBL4454039)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed