BDBM50527652 CHEMBL4454426

SMILES Clc1cc(ccc1Cn1nccc1-c1cc2n(nnc2cn1)-c1ccc2[nH]c(=O)[nH]c2c1)C#N

InChI Key InChIKey=RGZFRJRRTRMCMU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50527652   

Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527652(CHEMBL4454426)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human CD73 expressed in CHO cells in 2 % DMSO using AMP as substrate preincubated for 60 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527652(CHEMBL4454426)
Affinity DataIC50: 3.62E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using S-mephenytoin as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527652(CHEMBL4454426)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527652(CHEMBL4454426)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527652(CHEMBL4454426)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527652(CHEMBL4454426)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527652(CHEMBL4454426)
Affinity DataIC50: 1.38E+5nMAssay Description:Inhibition of recombinant human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed