BDBM50528926 CHEMBL4565200

SMILES Cc1cc(C(N)=O)c(s1)-c1cccc(OC(=O)NCCN2CCN(CC2)c2ccccc2)c1

InChI Key InChIKey=COGCORROFSOJTQ-UHFFFAOYSA-N

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50528926   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50528926(CHEMBL4565200)
Affinity DataIC50: 280nMAssay Description:Inhibition of human ERG expressed in HEK293 cells incubated for 72 hrs by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50528926(CHEMBL4565200)
Affinity DataIC50: 26nMAssay Description:Inhibition of FAAH in mouse brain membranes using [14C]-AEA as substrate incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50528926(CHEMBL4565200)
Affinity DataIC50: 282nMAssay Description:Inhibition of human ERG expressed in HEK293 cells incubated for 72 hrs by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50528926(CHEMBL4565200)
Affinity DataKi:  6.90nMAssay Description:Inhibition of FAAH in mouse brain membranes assessed as inhibitory constant using [14C]-AEA as substrate incubated for 15 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50528926(CHEMBL4565200)
Affinity DataKi:  148nMAssay Description:Displacement of [3H]-spiperone from human D3 receptor expressed in CHO cells co-expressing Galpha16 incubated for 120 mins by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50528926(CHEMBL4565200)
Affinity DataKi:  148nMAssay Description:Displacement of [3H]-spiperone from human D3 receptor expressed in CHO cells co-expressing Galpha16 incubated for 120 mins by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50528926(CHEMBL4565200)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]-spiperone from human D2 receptor expressed in CHO cells co-expressing Galpha16 incubated for 120 mins by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50528926(CHEMBL4565200)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]-spiperone from human D2 receptor expressed in CHO cells co-expressing Galpha16 incubated for 120 mins by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed