BDBM50529406 CHEMBL4525459

SMILES COc1nc(N)nc2n(nc(-c3ccc4oc(N)nc4c3)c12)C(C)C

InChI Key InChIKey=UAOGXXRABSNPRZ-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529406   

LigandPNGBDBM50529406(CHEMBL4525459)
Affinity DataKi:  250nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529406(CHEMBL4525459)
Affinity DataKi:  370nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529406(CHEMBL4525459)
Affinity DataIC50: 420nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529406(CHEMBL4525459)
Affinity DataIC50: 680nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed