BDBM50529875 CHEMBL4580000

SMILES Fc1ccc(cc1)-c1ccncc1\C=C\C(=O)Nc1ccc(CCc2nnco2)cc1

InChI Key InChIKey=IICSXHYHGAAWBA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529875   

TargetCyclin-C(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50529875(CHEMBL4580000)
Affinity DataIC50: 23nMAssay Description:Displacement of Kinase tracer 236 from recombinant full-length human N-terminal GST-fused CDK8 (1 to 464 residues)/cyclin C (1 to 283 residues) expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-C(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50529875(CHEMBL4580000)
Affinity DataIC50: 23nMAssay Description:Displacement of Kinase tracer 236 from recombinant full-length human N-terminal GST-fused CDK8 (1 to 464 residues)/cyclin C (1 to 283 residues) expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50529875(CHEMBL4580000)
Affinity DataIC50: 62nMAssay Description:Displacement of Kinase tracer 236 from GST-fused CDK19/cyclin C (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50529875(CHEMBL4580000)
Affinity DataIC50: 62nMAssay Description:Displacement of Kinase tracer 236 from GST-fused CDK19/cyclin C (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed