BDBM5053 2,5-dicyano-N-[(2Z)-3,4-dimethyl-5-(propan-2-yl)-2,3-dihydro-1,3-thiazol-2-ylidene]benzene-1-sulfonamide::YM-228855::thiazolidenebenzenesulfonamide deriv.

SMILES CC(C)c1s\c(=N/S(=O)(=O)c2cc(ccc2C#N)C#N)n(C)c1C

InChI Key InChIKey=DCWVQZINYPVHTH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5053   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5053(thiazolidenebenzenesulfonamide deriv. | 2,5-dicyan...)
Affinity DataIC50: 12nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5053(thiazolidenebenzenesulfonamide deriv. | 2,5-dicyan...)
Affinity DataIC50: 4.10E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5053(thiazolidenebenzenesulfonamide deriv. | 2,5-dicyan...)
Affinity DataIC50: 470nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2005
Entry Details Article
PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM5053(thiazolidenebenzenesulfonamide deriv. | 2,5-dicyan...)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant by HeLa-MAGI assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed