BDBM50530265 CHEMBL4559739

SMILES Clc1ccc(cc1Cl)-c1nc(NC(=O)CC#N)cs1

InChI Key InChIKey=CCXHNQKXOCPCFZ-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50530265   

TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530265(CHEMBL4559739)
Affinity DataIC50: 126nMAssay Description:Displacement of Myr-GQQPGKVLGDQRRPSL(K-TAMRA)G-amide from N-terminal-truncated human c-ABL D382N mutant (46 to 534 residues) after 30 mins by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530265(CHEMBL4559739)
Affinity DataIC50: 126nMAssay Description:Displacement of Myr-GQQPGKVLGDQRRPSL(K-TAMRA)G-amide from N-terminal-truncated human c-ABL D382N mutant (46 to 534 residues) after 30 mins by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530265(CHEMBL4559739)
Affinity DataIC50: 1.59E+3nMAssay Description:Activation of full length human 6His-tagged c-Abl expressed in baculovirus expression system using abltide as substrate after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530265(CHEMBL4559739)
Affinity DataIC50: 1.59E+3nMAssay Description:Activation of full length human 6His-tagged c-Abl expressed in baculovirus expression system using abltide as substrate after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530265(CHEMBL4559739)
Affinity DataEC50:  1.58E+4nMAssay Description:Induction of human c-ABL phosphorylation at Y245/Y412 residues in bacmam-induced HEK-MSR2 cell lysates by in-cell Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530265(CHEMBL4559739)
Affinity DataEC50:  1.58E+4nMAssay Description:Induction of human c-ABL phosphorylation at Y245/Y412 residues in bacmam-induced HEK-MSR2 cell lysates by in-cell Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed