BDBM50530768 CHEMBL4590582

SMILES Fc1ccc(-c2ccc(NC(=O)Nc3ccc(Cl)cc3)s2)c(F)c1

InChI Key InChIKey=BIRXGLNJESDGTF-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50530768   

TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 22nMAssay Description:Allosteric modulator activity at human CB1 receptor expressed in CHO-RD-HGA16 cells co-expressing Galpha16 assessed as suppression of 100 nM CP55,940...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 22nMAssay Description:Allosteric modulator activity at human CB1 receptor expressed in CHO-RD-HGA16 cells co-expressing Galpha16 assessed as suppression of 100 nM CP55,940...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 48nMAssay Description:Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 1 uM CP55,940-induced [35S]GTPgammaS binding i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 48nMAssay Description:Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 1 uM CP55,940-induced [35S]GTPgammaS binding i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 48nMAssay Description:Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 1 uM CP55,940-induced [35S]GTPgammaS binding i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 48nMAssay Description:Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 1 uM CP55,940-induced [35S]GTPgammaS binding i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 84nMAssay Description:Allosteric modulator activity at human CB1 receptor expressed in HEK293 cell membranes assessed as suppression of 100 nM CP55,940-induced [35S]GTPgam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 84nMAssay Description:Allosteric modulator activity at human CB1 receptor expressed in HEK293 cell membranes assessed as suppression of 100 nM CP55,940-induced [35S]GTPgam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 138nMAssay Description:Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 100 nM CP55,940-induced [35S]GTPgammaS binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 138nMAssay Description:Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 100 nM CP55,940-induced [35S]GTPgammaS binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 138nMAssay Description:Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 100 nM CP55,940-induced [35S]GTPgammaS binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 138nMAssay Description:Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 100 nM CP55,940-induced [35S]GTPgammaS binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 2.29E+3nMAssay Description:Allosteric modulator activity at human CB1 receptor expressed in HEK293 cells assessed as suppression of 100 nM CP55,940-induced reduction in forskol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 2.29E+3nMAssay Description:Allosteric modulator activity at human CB1 receptor expressed in HEK293 cells assessed as suppression of 100 nM CP55,940-induced reduction in forskol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of EC80 CP55,940-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50530768(CHEMBL4590582)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of EC80 CP55,940-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed