BDBM50531305 CHEMBL4453937

SMILES Clc1ccc(cc1)-c1ccnc2nc([nH]c(=O)c12)N1CCCC1

InChI Key InChIKey=DWHZEYYOVXBBBO-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50531305   

TargetAdenosine receptor A1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50531305(CHEMBL4453937)
Affinity DataKi:  776nMAssay Description:Displacement of [3H]DPCPX from human A1AR expressed in CHO cells incubated for 50 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50531305(CHEMBL4453937)
Affinity DataKi:  776nMAssay Description:Displacement of [3H]DPCPX from human A1AR expressed in CHO cells incubated for 50 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50531305(CHEMBL4453937)
Affinity DataIC50: 1.48E+3nMAssay Description:Binding affinity to human adenosine A1A receptor measured by radioligand-based affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50531305(CHEMBL4453937)
Affinity DataIC50: 1.86E+3nMAssay Description:Antagonist activity at human A1AR expressed in CHO-K1 cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50531305(CHEMBL4453937)
Affinity DataIC50: 1.86E+3nMAssay Description:Antagonist activity at human A1AR expressed in CHO-K1 cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50531305(CHEMBL4453937)
Affinity DataKi: <1.00E+5nMAssay Description:Displacement of [3H]ZM241385 from human A2AR expressed in CHO cells after 90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50531305(CHEMBL4453937)
Affinity DataKi: <1.00E+5nMAssay Description:Displacement of [3H]ZM241385 from human A2AR expressed in CHO cells after 90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed