BDBM50531400 CHEMBL4435688

SMILES CCOc1cc(O)c(cc1CN1CCC=C(C1)n1c2ccccc2[nH]c1=O)C(=O)\C=C\c1ccc(Cl)cc1Cl

InChI Key InChIKey=KXGGLZVQMDYPEO-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50531400   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50531400(CHEMBL4435688)
Affinity DataIC50: 7.67E+3nMAssay Description:Inhibition of recombinant full length human GST-tagged SHP2 E76K mutant using pNPP as substrate pre-incubated for 15 mins before pNPP substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50531400(CHEMBL4435688)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of wild type recombinant human SHP2 using H-Glu-Phe-pTyr-Ala-Glu-Val-Gly-Arg-Ser-Pro-Pro-Asp-Pro-Ala-Lys as substrate preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50531400(CHEMBL4435688)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of recombinant full length human GST-tagged SHP2 PTP domain using pNPP as substrate pre-incubated for 15 mins before pNPP substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50531400(CHEMBL4435688)
Affinity DataKd:  6.90E+4nMAssay Description:Binding affinity to full length wild type His-tagged SHP2 (unknown origin) by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50531400(CHEMBL4435688)
Affinity DataIC50: 7.27E+4nMAssay Description:Inhibition of wild type recombinant human SHP1 using H-Glu-Phe-pTyr-Ala-Glu-Val-Gly-Arg-Ser-Pro-Pro-Asp-Pro-Ala-Lys as substrate preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed