BDBM50531922 CHEMBL4471178

SMILES CC(C)n1cnc2c(NCc3cccc(c3)C(F)(F)F)ncnc12

InChI Key InChIKey=REKSFCCYDQMSIN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50531922   

TargetCasein kinase I isoform alpha(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50531922(CHEMBL4471178)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant full length human GST-tagged CK1apha expressed in baculovirus using peptide as substrate after 3 hrs by kinase-glo luminesc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50531922(CHEMBL4471178)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant N-terminal human GST-tagged CK1delta (1 to 294 residues) expressed in Escherichia coli using RKKKAEpSVASLTSQCSYSS peptide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50531922(CHEMBL4471178)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CDK2 (unknown origin) after 3 hrs by kinase-glo luminescent assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50531922(CHEMBL4471178)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant full length C-terminal human His-tagged CDK7/cyclin H/N-terminal MAT1 expressed in baculovirus expression system using Cdk7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50531922(CHEMBL4471178)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant full-length human MAPK1 expressed in Escherichia coli using MBP1 as substrate after 3 hrs by kinase-g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50531922(CHEMBL4471178)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of MAPK8 (unknown origin) using peptide as substrate after 3 hrs by kinase-glo luminescent assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed