BDBM50531947 CHEMBL4566096

SMILES COC(=O)N[C@H](CN1CCC[C@H]1c1ncc([nH]1)-c1ccc2c3c(Oc4cc(ccc4C3(C)C)-c3cnc([nH]3)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OC)C3CCOCC3)ccc2c1)C1CCOCC1

InChI Key InChIKey=NYHLHLSQADEMRW-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50531947   

TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531947(CHEMBL4566096)
Affinity DataEC50:  0.0800nMAssay Description:Inhibition of NS5A in HCV genotype 3a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531947(CHEMBL4566096)
Affinity DataEC50:  0.00200nMAssay Description:Inhibition of NS5A in HCV genotype 1a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531947(CHEMBL4566096)
Affinity DataEC50:  0.700nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 1a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531947(CHEMBL4566096)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 4a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531947(CHEMBL4566096)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 1b assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531947(CHEMBL4566096)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of NS5A in HCV genotype 2b assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed