BDBM50532765 CHEMBL4436706

SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4cccnn34)cc2s1

InChI Key InChIKey=NCUXYLOSWNSCIT-UHFFFAOYSA-N

Data  6 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50532765   

TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532765(CHEMBL4436706)
Affinity DataKd:  12nMAssay Description:Binding affinity to MET (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532765(CHEMBL4436706)
Affinity DataKd:  12nMAssay Description:Binding affinity to MET (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532765(CHEMBL4436706)
Affinity DataIC50: 29nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532765(CHEMBL4436706)
Affinity DataIC50: 29nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532765(CHEMBL4436706)
Affinity DataIC50: 4.81E+3nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532765(CHEMBL4436706)
Affinity DataIC50: 4.81E+3nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532765(CHEMBL4436706)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532765(CHEMBL4436706)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed