BDBM50533146 CHEMBL4573466

SMILES Cc1c2COC(=O)c2ccc1C(F)CN1CCN(CC(F)c2ccc3C(=O)OCc3c2C)CC1

InChI Key InChIKey=VYYGLESFPYPITB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50533146   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50533146(CHEMBL4573466)
Affinity DataIC50: 96nMAssay Description:Inhibition of ROMK (unknown origin) after 30 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50533146(CHEMBL4573466)
Affinity DataIC50: 96nMAssay Description:Inhibition of ROMK (unknown origin) after 30 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50533146(CHEMBL4573466)
Affinity DataIC50: 117nMAssay Description:Inhibition of ROMK (unknown origin) expressed in CHO cells after 6 mins by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50533146(CHEMBL4573466)
Affinity DataIC50: 117nMAssay Description:Inhibition of ROMK (unknown origin) expressed in CHO cells after 6 mins by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50533146(CHEMBL4573466)
Affinity DataIC50: 4.00E+4nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50533146(CHEMBL4573466)
Affinity DataIC50: 4.00E+4nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50533146(CHEMBL4573466)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human ERG after 6 mins by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50533146(CHEMBL4573466)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human ERG after 6 mins by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed