BDBM50533258 CHEMBL4435231

SMILES CNC(=O)[C@@H]1C[C@@H](CN1C(=O)c1ccc(CN)c(OC)c1)N1CCc2c(C1)cccc2OCCc1ccccc1

InChI Key InChIKey=PAZGSUVUHZFUIE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533258   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533258(CHEMBL4435231)
Affinity DataIC50: 4.00E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533258(CHEMBL4435231)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533258(CHEMBL4435231)
Affinity DataIC50: 4.00E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533258(CHEMBL4435231)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed