BDBM50533496 CHEMBL4438330

SMILES CCn1nc(cc1Nc1nc(cs1)-c1ccc(c(F)c1)-n1cnc(C)c1)C(C)(C)C

InChI Key InChIKey=VPTWIQNXYBDCCO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50533496   

TargetCytochrome P450 3A4(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 63nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 8.20E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 63nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed