BDBM50533700 CHEMBL4471376

SMILES CCOC(=O)c1c(NC(=O)C(C)Sc2nnc(CNC(=O)c3cc(OC)cc(OC)c3)n2-c2ccccc2OC)sc2CCCc12

InChI Key InChIKey=GJLLOKTZLWBJEY-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50533700   

TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533700(CHEMBL4471376)
Affinity DataIC50: 700nMAssay Description:Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533700(CHEMBL4471376)
Affinity DataKi:  800nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533700(CHEMBL4471376)
Affinity DataKi:  1.00E+3nMAssay Description:Antagonist activity at human OX2 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation after 30 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533700(CHEMBL4471376)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533700(CHEMBL4471376)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533700(CHEMBL4471376)
Affinity DataKi:  7.00E+3nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation after 30 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed