BDBM50533701 CHEMBL4548914

SMILES Cc1cccc2c3nnc(N\N=C/c4c5ccccc5cc5ccccc45)nc3[nH]c12

InChI Key InChIKey=BDUKBHXDUOFMQX-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50533701   

TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533701(CHEMBL4548914)
Affinity DataIC50: 300nMAssay Description:Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533701(CHEMBL4548914)
Affinity DataKi:  400nMAssay Description:Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533701(CHEMBL4548914)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533701(CHEMBL4548914)
Affinity DataIC50: 1.90E+3nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533701(CHEMBL4548914)
Affinity DataKi:  1.10E+4nMAssay Description:Antagonist activity at human OX2 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation after 30 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533701(CHEMBL4548914)
Affinity DataKi:  1.62E+4nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation after 30 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed