BDBM50533703 CHEMBL4473709

SMILES COc1ccccc1N1C(=O)c2ccccc2NC11C(=O)N(CC=C)c2ccccc12

InChI Key InChIKey=ICNRHSXEHSIYCI-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50533703   

TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533703(CHEMBL4473709)
Affinity DataIC50: 700nMAssay Description:Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533703(CHEMBL4473709)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533703(CHEMBL4473709)
Affinity DataKi:  1.20E+3nMAssay Description:Antagonist activity at human OX2 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation after 30 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533703(CHEMBL4473709)
Affinity DataKi:  1.20E+4nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533703(CHEMBL4473709)
Affinity DataIC50: 2.09E+4nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50533703(CHEMBL4473709)
Affinity DataKi:  2.16E+4nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation after 30 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed