BDBM50535082 CHEMBL4466696

SMILES Cn1cc(cn1)-c1cc2nccnc2c(NC[C@@H]2CNCCO2)n1

InChI Key InChIKey=UAUJVWLUSNTVTA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50535082   

TargetAurora kinase B(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B in calyculin stimulated human HT29 cells assessed as reduction in phosphorylation of histone H3 at ser10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal-6His-tagged full length human Aurora B expressed in baculovirus using 5FAM-PKA-tide as substrate after 120 mins by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cell membranes after 2 hrs by cy3b-dofetilide-based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 251nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 501nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 158nMAssay Description:Inhibition of SYK in human B cells assessed as suppression of anti-IgM-induced CD69 surface expression preincubated for 30 mins followed by anti-IgM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 251nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 63nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535082(CHEMBL4466696)
Affinity DataIC50: 100nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed