BDBM50535110 CHEMBL4570285

SMILES C(Nc1nc(cc2nccnc12)-c1cn[nH]c1)[C@H]1CCCNC1

InChI Key InChIKey=MTOXIGVDKCMGPO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50535110   

TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535110(CHEMBL4570285)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535110(CHEMBL4570285)
Affinity DataIC50: 316nMAssay Description:Inhibition of SYK in human B cells assessed as suppression of anti-IgM-induced CD69 surface expression preincubated for 30 mins followed by anti-IgM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535110(CHEMBL4570285)
Affinity DataIC50: 398nMAssay Description:Inhibition of N-terminal-6His-tagged full length human Aurora B expressed in baculovirus using 5FAM-PKA-tide as substrate after 120 mins by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50535110(CHEMBL4570285)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cell membranes after 2 hrs by cy3b-dofetilide-based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed