BDBM50535665 CHEMBL4443536

SMILES OC(=O)c1ccc(C(=O)N2CCc3nc([nH]c(=O)c3C2)-c2ccccc2)c2ccccc12

InChI Key InChIKey=AZXAVMXQBBGJGS-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50535665   

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Daiichi Sankyo

Curated by ChEMBL

LigandBDBM50535665(CHEMBL4443536)Copy SMILESCopy InChI

Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NAD and formaldehyde incuba...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/28/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL