BDBM50536666 CHEMBL4588797

SMILES c1c(c2c(ncnc2n1[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N)C#N

InChI Key InChIKey=XLTWYAYAFLGUEQ-UHFFFAOYSA-N

Data  6 IC50

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50536666   

TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50536666(CHEMBL4588797)
Affinity DataIC50: 26nMAssay Description:Inhibition of DOT1L (unknown origin) using chicken nucleosome as substrate in presence of [3H]SAM incubated for 1 hr by TopCount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 3(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50536666(CHEMBL4588797)
Affinity DataIC50: 870nMAssay Description:Inhibition of PRMT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50536666(CHEMBL4588797)
Affinity DataIC50: 9.90E+4nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50536666(CHEMBL4588797)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant DOT1L (1 to 420 amino acids) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50536666(CHEMBL4588797)
Affinity DataIC50: 150nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50536666(CHEMBL4588797)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed