BDBM50536790 CHEMBL4575118

SMILES Cc1ccc(cc1)-c1nn(cc1C(=O)NOCc1ccccc1F)-c1ccccc1

InChI Key InChIKey=HVEABAGWWBLXHR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50536790   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged C-terminal His6-tagged MEK1 expressed in Escherichia coli using myelin basic protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: 610nMAssay Description:Inhibition of MEK1 in BRAF mutant human A549 cells assessed as reduction in ERK1/2 phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of FAK in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed