BDBM50536933 CHEMBL4061054

SMILES COc1cc(ccc1OS(C)(=O)=O)-c1nc2ccccc2c(=O)[nH]1

InChI Key InChIKey=NPVBHWSQIGVFRG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50536933   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536933(CHEMBL4061054)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4 (S4 to E303 residues)/Cyclin D1 (Q4 to I295 residues) expressed in sf9 cells using RBCTF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536933(CHEMBL4061054)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal GST-HIS6 fusion protein tagged human full length CDK9 (M1 to F372 residues)/N-terminal HIS6-fused human Cyclin-T1 (M1 to K72...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536933(CHEMBL4061054)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) using RBER-CHKtide as substrate measured after 1 hr by ADP-glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536933(CHEMBL4061054)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in baker's yeast-derived microsomes using 3-cyano-7-ethoxycoumarin as substrate by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536933(CHEMBL4061054)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human full length N-terminal GST-fused CDK2 (M1 to L298 residues)/human full length Cyclin-A2 (M1 to L432 residues) expressed in Sf9 ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536933(CHEMBL4061054)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in baker's yeast-derived microsomes using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536933(CHEMBL4061054)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged CDK1 (M1 to M297 residues)/CyclinB1 (M1 to V433 residues) expressed in Sf9 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536933(CHEMBL4061054)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in baker's yeast-derived microsomes using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed