BDBM50537601 CHEMBL4643993::US11149020, Compound 49 (MW-203)

SMILES CN1CCN(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccc2cc(F)ccc2c1

InChI Key InChIKey=DWYNWJSIUIDKFP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50537601   

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537601(CHEMBL4643993 | US11149020, Compound 49 (MW-203))
Affinity DataIC50: 1.18E+3nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM50537601(CHEMBL4643993 | US11149020, Compound 49 (MW-203))
Affinity DataIC50: 6.35E+3nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537601(CHEMBL4643993 | US11149020, Compound 49 (MW-203))
Affinity DataIC50: 920nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537601(CHEMBL4643993 | US11149020, Compound 49 (MW-203))
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM50537601(CHEMBL4643993 | US11149020, Compound 49 (MW-203))
Affinity DataIC50: 5.21E+3nMAssay Description:Inhibition of human CK1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed