BDBM50541977 CHEMBL4647524

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1cc(OC)ncn1)[C@H]2Nc1nc2C(CCCCn2n1)c1ccc(F)c(F)c1F

InChI Key InChIKey=FIJWVLHCGSBUTG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50541977   

TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50541977(CHEMBL4647524)
Affinity DataIC50: 29nMAssay Description:Modulation of gamma secretase in human H4 cells overexpressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in tota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50541977(CHEMBL4647524)
Affinity DataIC50: 550nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed