BDBM50542082 CHEMBL4645364

SMILES C[C@@H](COc1cc(F)c([C@H]2N(CC(C)(C)F)[C@H](C)Cc3c2[nH]c2ccccc32)c(F)c1)N1CC[C@@H](CF)C1

InChI Key InChIKey=NYLZWQVRLPAJQO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50542082   

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542082(CHEMBL4645364 | US20250114338, Example 108)
Affinity DataEC50:  0.110nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542082(CHEMBL4645364 | US20250114338, Example 108)
Affinity DataIC50: 0.210nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed