BDBM50542205 CHEMBL4643875

SMILES [H][C@]1(CCN(C1)c1c(F)cc2cc(C(O)=O)c(=O)n(C3CC3)c2c1C)[C@H](C)N

InChI Key InChIKey=WDEFFRJHKJGSLD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542205   

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542205(CHEMBL4643875)
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542205(CHEMBL4643875)
Affinity DataIC50: 2.14E+5nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542205(CHEMBL4643875)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed