BDBM50542735 CHEMBL4635286

SMILES CC(C)c1cc(CCN2CCc3cccc(C(O)=O)c23)cc(c1)-c1ccc2OC[C@@H](N)c2c1

InChI Key InChIKey=CQQFREVZNRVIIM-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50542735   

TargetCoagulation factor XI(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 6nMAssay Description:Inhibition of human F11a using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 220nMAssay Description:Inhibition of N-terminal human plasma F11a catalytic domain expressed in Escherichia coli strain BL21(DE3) using D-Leu-Pro-Arg*Rh110-D-Pro as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 6.23E+3nMAssay Description:Inhibition of human F7a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human F9a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human F10a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of human thrombin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 58nMAssay Description:Inhibition of PKL (unknown origin) using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 660nMAssay Description:Inhibition of human tPa using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of human plasmin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 520nMAssay Description:Inhibition of human uPA using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 4.41E+3nMAssay Description:Inhibition of human complement FD by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 6nMAssay Description:Inhibition of FXIa (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 58nMAssay Description:Inhibition of PKal (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542735(CHEMBL4635286)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of FD (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed