BDBM50543927 CHEMBL4644662

SMILES OC(C(=C)C#N)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12

InChI Key InChIKey=PVDVXVZXCRACGR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50543927   

TargetTyrosine-protein kinase JAK1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543927(CHEMBL4644662)
Affinity DataIC50: 95nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543927(CHEMBL4644662)
Affinity DataIC50: 55nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543927(CHEMBL4644662)
Affinity DataIC50: 285nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543927(CHEMBL4644662)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of JAK1 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543927(CHEMBL4644662)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of JAK2 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543927(CHEMBL4644662)
Affinity DataIC50: 7.05E+3nMAssay Description:Inhibition of JAK3 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed