BDBM50544405 CHEMBL4634857

SMILES COc1cc(cc(OC)c1OC)-c1cncc(c1C)-c1ccc(cc1)N1C[C@H](C)N[C@H](C)C1

InChI Key InChIKey=RPZNNVBZIMEQNF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50544405   

TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544405(CHEMBL4634857)
Affinity DataIC50: 8nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544405(CHEMBL4634857)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544405(CHEMBL4634857)
Affinity DataIC50: 40nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544405(CHEMBL4634857)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544405(CHEMBL4634857)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells after 5 mins by IonWorks barracuda patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed