BDBM50544830 CHEMBL4635876

SMILES OCCn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1

InChI Key InChIKey=NROLQUCDBSGNQD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50544830   

TargetTyrosine-protein kinase JAK1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50544830(CHEMBL4635876)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50544830(CHEMBL4635876)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50544830(CHEMBL4635876)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50544830(CHEMBL4635876)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC cells assessed as reduction in IL2-induced IFNgamma productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed