BDBM50544862 CHEMBL4645611::US11292781, Compound T83

SMILES [H][C@]12CCc3c(nc(nc3[C@]1(C)C=C(C#N)C(=O)[C@@H]2C)-c1ccnc(CF)c1)-c1ccccc1F

InChI Key InChIKey=VNOZLDIRUBEPCM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544862   

TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544862(CHEMBL4645611 | US11292781, Compound T83)
Affinity DataIC50: 35nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544862(CHEMBL4645611 | US11292781, Compound T83)
Affinity DataIC50: 72nMAssay Description:The RORγ assay system was purchased from Indigo Biosciences. This nuclear receptor assay utilizes a human cell line that has been engineered to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544862(CHEMBL4645611 | US11292781, Compound T83)
Affinity DataIC50: 74nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed