BDBM50545822 CHEMBL4644009

SMILES COc1cc(\C=C2/CCCN3[C@@H](C)[C@@H](ON=C23)c2cc(F)cc(F)c2)ccc1-n1cnc(C)c1

InChI Key InChIKey=UXDBRWRDVOSHLO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50545822   

TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50545822(CHEMBL4644009)
Affinity DataIC50: 9.29E+3nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed