BDBM50545823 CHEMBL4637679

SMILES COc1cc(\C=C2/CCCN3[C@@H](C(C)C)[C@H](ON=C23)c2cc(F)cc(F)c2)ccc1-n1cnc(C)c1

InChI Key InChIKey=MVZXEPQFNQOZSR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50545823   

TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50545823(CHEMBL4637679)
Affinity DataIC50: 113nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed