BDBM50545934 CHEMBL4761474

SMILES Cc1cc(cn(C)c1=O)-c1ccc2nc(nc(N3CCOC[C@@H]3c3ccc(F)cc3)c2c1)-c1cnn(CC(C)(C)O)c1

InChI Key InChIKey=RGEHEZQEUQCGHU-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50545934   

TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545934(CHEMBL4761474)
Affinity DataIC50: 6nMAssay Description:Inhibition of human full-length recombinant N-terminal His-tagged BRD4 (2 to 1362 residues) expressed in Sf9 cells using histone H4 peptide containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545934(CHEMBL4761474)
Affinity DataKd:  20nMAssay Description:Competitive binding affinity to human partial length BRD4 (BD1,2) (N44 to E460 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545934(CHEMBL4761474)
Affinity DataKd: <100nMAssay Description:Binding affinity to DNA-tagged human BRD4 (BD1,2) isoform long expressed in Escherichia coli BL21 incubated for 1 hr by competitive ligand binding BR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545934(CHEMBL4761474)
Affinity DataIC50: 100nMAssay Description:Inhibition of binding of N-terminal His-tagged human full length recombinant BRD4 (2 to 1362 residues) expressed in baculovirus-infected Sf9 cells wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed