BDBM50545938 CHEMBL4780320

SMILES Fc1cccc(c1)-c1nc2sccn2c1-c1ccnc(NCCNS(=O)(=O)c2ccc(cc2)C(F)(F)F)n1

InChI Key InChIKey=WMMCWNRDLKCWCI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50545938   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50545938(CHEMBL4780320)
Affinity DataIC50: 88nMAssay Description:Inhibition of human CRAF using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50545938(CHEMBL4780320)
Affinity DataIC50: 22nMAssay Description:Inhibition of human BRAF V600E mutant using MEK1 as substrate by [gamma-34P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50545938(CHEMBL4780320)
Affinity DataIC50: 85nMAssay Description:Inhibition of human BRAF using MEK1 as substrate by [gamma-34P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed