BDBM50546017 CHEMBL4779432

SMILES CNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)c(COc2cccc3c(cc(C)nc23)C(F)(F)F)c1Cl

InChI Key InChIKey=XXLHCSHDXFDLHN-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50546017   

TargetNuclear receptor ROR-gamma(Human)
Inventiva

Curated by ChEMBL
LigandPNGBDBM50546017(CHEMBL4779432)
Affinity DataEC50:  210nMAssay Description:Inverse agonist activity at RORgamma in human CD4+ T cells assessed as inhibition of IL17A secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Inventiva

Curated by ChEMBL
LigandPNGBDBM50546017(CHEMBL4779432)
Affinity DataEC50:  250nMAssay Description:Inverse agonist activity at pSG5GAL4-DBD/LBD fused human RORgamma receptor expressed in COS7 cells co-expressing 5 copies of GAL4 response element af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed