BDBM50546023 CHEMBL4749883

SMILES Cc1cc(c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)N3CCCC3)c2n1)C(F)(F)F

InChI Key InChIKey=GAUJNVOGXRINCZ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50546023   

TargetNuclear receptor ROR-gamma(Human)
Inventiva

Curated by ChEMBL
LigandPNGBDBM50546023(CHEMBL4749883)
Affinity DataEC50:  300nMAssay Description:Inverse agonist activity at RORgamma in human CD4+ T cells assessed as inhibition of IL17A secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Inventiva

Curated by ChEMBL
LigandPNGBDBM50546023(CHEMBL4749883)
Affinity DataEC50:  810nMAssay Description:Inverse agonist activity at pSG5GAL4-DBD/LBD fused human RORgamma receptor expressed in COS7 cells co-expressing 5 copies of GAL4 response element af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed