BDBM50546134 CHEMBL4755729

SMILES CN(C)c1ccc(CC(=O)N[C@@H]2CNC[C@H]2c2ccc(cc2)S(F)(F)(F)(F)F)cc1

InChI Key InChIKey=RXDSEFSJXGLOIL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50546134   

TargetCytochrome P450 2C19(Human)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50546134(CHEMBL4755729)
Affinity DataIC50: 2.94E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in baculovirus infected insect cells using s-mephenytoin as substrate incubated for 30 mins in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50546134(CHEMBL4755729)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in baculovirus infected insect cells using tolbutamide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50546134(CHEMBL4755729)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in baculovirus infected insect cells using dextromethorphan as substrate incubated for 30 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50546134(CHEMBL4755729)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in baculovirus infected insect cells using phenacetin as substrate incubated for 30 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50546134(CHEMBL4755729)
Affinity DataIC50: 159nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculovirus infected insect cells using midazolam as substrate incubated for 30 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50546134(CHEMBL4755729)
Affinity DataIC50: 2.57E+3nMAssay Description:Displacement of Tracer Red from human ERG incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed