BDBM50546178 CHEMBL4744271

SMILES Cc1c(NC(=O)c2ccc(cc2)C2CC2)cc(F)cc1-c1ncnc2[nH]cc(C3CCCN(C3)C(=O)C=C)c12

InChI Key InChIKey=QSKCZEFIQCPTOC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50546178   

TargetTyrosine-protein kinase BTK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546178(CHEMBL4744271)
Affinity DataIC50: 390nMAssay Description:Inhibition of full length human unphosphorylated BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate incubated for 60 mins in presence of ATP at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546178(CHEMBL4744271)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in polyclonal anti-IgM antibody/human IL4-stimulated CD69 cell surface expression on B c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed