BDBM50546223 CHEMBL4740286::US20240092795, Example 2

SMILES N[C@@H]1CCCC11CCN(CC1)c1cc(O)c(Sc2cccc(Cl)c2Cl)nc1CO

InChI Key InChIKey=RZOJWRSBEIBPBF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50546223   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546223(CHEMBL4740286 | US20240092795, Example 2)
Affinity DataIC50: 37nMAssay Description:Allosteric inhibition of activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins followed by substrate addition by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546223(CHEMBL4740286 | US20240092795, Example 2)
Affinity DataIC50: 37nMAssay Description:The catalytic activity of SHP2 was monitored using the surrogate substrate DiFMUP in a prompt fluorescence assay format.The phosphatase reactions wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent