BDBM50546748 CHEMBL4744486

SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccc2nc(NC(=O)c3ccccc3)cn2n1

InChI Key InChIKey=XFVLTXDWQPOCLQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50546748   

LigandPNGBDBM50546748(CHEMBL4744486)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50546748(CHEMBL4744486)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged full-length human PI3K p110alpha/human p85alpha co- expressed in Sf9 insect cells using phosphatidyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50546748(CHEMBL4744486)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full-length human PI3K p110delta/p85alpha co- expressed in Sf9 insect cells using phosphatidylinosito...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50546748(CHEMBL4744486)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at S473 residue incubated for 60 mins by alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed