BDBM50546765 CHEMBL4742062

SMILES CC(C)c1cc(ccc1C(O)=O)-c1cnn2ccc(nc12)-c1cc2CN([C@@H](C)C3CC3)C(=O)c2c(c1)C(F)(F)F

InChI Key InChIKey=VHCSLWRCKYDLOT-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50546765   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Arcus Biosciences

Curated by ChEMBL

LigandBDBM50546765(CHEMBL4742062)Copy SMILESCopy InChI

Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/21/2022
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Arcus Biosciences

Curated by ChEMBL

LigandBDBM50546765(CHEMBL4742062)Copy SMILESCopy InChI

Affinity DataIC50: 74nMAssay Description:Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at S473 residue incubated for 60 mins by alphalisa assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/21/2022
Entry Details Article
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Arcus Biosciences

Curated by ChEMBL

LigandBDBM50546765(CHEMBL4742062)Copy SMILESCopy InChI

Affinity DataIC50: 194nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged full-length human PI3K p110alpha/human p85alpha co- expressed in Sf9 insect cells using phosphatidyl...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/21/2022
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Arcus Biosciences

Curated by ChEMBL

LigandBDBM50546765(CHEMBL4742062)Copy SMILESCopy InChI

Affinity DataIC50: 459nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full-length human PI3K p110delta/p85alpha co- expressed in Sf9 insect cells using phosphatidylinosito...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/21/2022
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Arcus Biosciences

Curated by ChEMBL

LigandBDBM50546765(CHEMBL4742062)Copy SMILESCopy InChI

Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged full-length human PI3K p110beta/human p85alpha co- expressed in Sf9 insect cells using phosphatidyli...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/21/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL