BDBM50547848 CHEMBL4741884

SMILES Cc1c(cccc1-n1c(=O)cc2ccccn2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O

InChI Key InChIKey=ZBUAACUFPJCODX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50547848   

TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50547848(CHEMBL4741884)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant full-length His-tagged human BTK expressed in baculovirus expression system using fluoresceinated peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50547848(CHEMBL4741884)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant full-length His-tagged human BTK expressed in baculovirus expression system using fluoresceinated peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50547848(CHEMBL4741884)
Affinity DataIC50: 19nMAssay Description:Inhibition of BTK in human Ramos B cells assessed as reduction in goat anti human IgM-stimulated calcium flux preincubated for 1 hr followed by goat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50547848(CHEMBL4741884)
Affinity DataIC50: 19nMAssay Description:Inhibition of BTK in human Ramos B cells assessed as reduction in goat anti human IgM-stimulated calcium flux preincubated for 1 hr followed by goat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50547848(CHEMBL4741884)
Affinity DataIC50: 410nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in goat anti human IgM/human IL4-stimulated CD69 cell surface expression on peripheral B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed