BDBM50547849 CHEMBL4789404

SMILES COc1ccn2c(c1)cc(=O)n(-c1cccc(c1C)-c1ccc(C(N)=O)c3[nH]c4cc(ccc4c13)C(C)(C)O)c2=O

InChI Key InChIKey=HPPFVYVYCRLUIG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50547849   

TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50547849(CHEMBL4789404)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of recombinant full-length His-tagged human BTK expressed in baculovirus expression system using fluoresceinated peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50547849(CHEMBL4789404)
Affinity DataIC50: 19nMAssay Description:Inhibition of BTK in human Ramos B cells assessed as reduction in goat anti human IgM-stimulated calcium flux preincubated for 1 hr followed by goat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50547849(CHEMBL4789404)
Affinity DataIC50: 140nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in goat anti human IgM/human IL4-stimulated CD69 cell surface expression on peripheral B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed