BDBM50549243 CHEMBL4791626::US11897863, Example 1

SMILES CN(C)CCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(cc2n1)C(C)(C)O

InChI Key InChIKey=QAOWCAZEVIIQTF-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50549243   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of IRAK4 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 0.550nMAssay Description:The following methods were used to determine the inhibition degree of the preferred compound of the present invention on IRAK4 kinase activity in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 55nMAssay Description:Inhibition of IRAK4 in human THP-1 cells by cell based anti-inflammatory assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Zhejiang Hisun Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50549243(CHEMBL4791626 | US11897863, Example 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed